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  • Title: Knowing when not to stop: selenocysteine incorporation in eukaryotes.
    Author: Low SC, Berry MJ.
    Journal: Trends Biochem Sci; 1996 Jun; 21(6):203-8. PubMed ID: 8744353.
    Abstract:
    The regulation of translation frequently involves protein-RNA interactions. An intriguing example of this is the alternative decoding of UGA, typically a stop codon, as selenocysteine. Two RNA structures, the mRNA selenocysteine insertion sequence (SECIS element) and a unique selenocysteyl-tRNA, are required for this process. In prokaryotes, a single RNA-binding protein, a selenocysteine-specific elongation factor, interacts with both the tRNA and mRNA to confer decoding. Whether eukaryotes use a similar mechanism is currently the subject of intense investigation.
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