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  • Title: Influence of gold salts treatment on the serum concentration of IL-1 and IL-2 in patients with rheumatoid arthritis.
    Author: Lewandowicz J, Dabkowska B, Nowak D.
    Journal: Arch Immunol Ther Exp (Warsz); 1995; 43(3-4):195-8. PubMed ID: 8744695.
    Abstract:
    Eighteen subjects (2 males, 16 females) with rheumatoid arthritis were treated with gold salts for 6 months. The statistically significant decrease of IL-1 and IL-2 levels during the treatment was observed. The mean serum concentrations of IL-1 and IL-2 decreased from 41.0 +/- 11.5 to 28.6 +/- 7.3 (p < 0.001) and 98.3 +/- 57.6 to 29.3 +/- 20.5 fmol/ml (p < 0.001), respectively. This decrease was accompanied by a decline of serum concentration of acute phase proteins and immunoglobulins. These results can explain a strong anti-inflammatory action of gold salts in patients with rheumatoid arthritis.
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