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  • Title: Effect of motilin on the L-leucine transport in rabbit jejunum.
    Author: Marco R, Navarro H, Rodriguez-Yoldi MJ, Sorribas V, Alcalde AI.
    Journal: Peptides; 1995; 16(8):1505-10. PubMed ID: 8745065.
    Abstract:
    Motilin is a gastrointestinal peptide that stimulates the gastrointestinal motility in several species. The aim of the present work has been to determine the effect of motilin on the L-leucine absorption in rabbit jejunum. The results show that motilin inhibits the L-leucine Na(+)-dependent system of transport located in the mucosal border mainly by diminishing the apparent Vmax. Motilin did not directly affect the Na(+)-dependent system of transport, but it seems to act across the protein kinase C (PKC). These results suggest that motilin may act as a regulatory hormone of the intestinal absorption of nutrients.
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