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  • Title: [Evaluation and its clinical significance of anti-platelet granule membrane protein-140 autoantibodies and anticalmodulin antibody in patients with severe pregnancy-induced hypertension].
    Author: Zhang S, Dong J, Liu B.
    Journal: Zhonghua Fu Chan Ke Za Zhi; 1995 Nov; 30(11):665-7. PubMed ID: 8745491.
    Abstract:
    OBJECTIVE: To study the effect of immune function of platelet on the pathogenesis of severe pregnancy-induced hypertension. METHODS: 46 plasma samples from patients with severe pregnancy-induced hypertension (PIH) were evaluated for autoantibodies directed against granule membrane protein-140 (GMP-140) and anticalmodulin antibody (A-CaM) using ELISA methods. RESULTS: Autoantibodies to GMP-140 existed in 13 patients with severe PIH (28.6%), after SDS-page of purified GMP-140 immunoblotting showed that 1 out of 8 sera from patients presented a staining band with M.W. of 140 kd. 29 plasma samples were found autoantibodies to GMP-140, GP IIb/IIIa and GP Ib/IX, simultaneously. It was shown that antiGMP-140 activities coexisted with anti-GP IIb/IIIa and/or anti-GPIb/Ix in 29 cases (81.8%). The elevated A-CaM was observed in the patients with severe PIH reaching to 20.02 +/- 3.74U/L, that was much higher than those from the normal (7.53 +/- 2.57U/L, P < 0.05). CONCLUSION: Our study provided the evidence for autoantibodies to GMP-140 and A-CaM in some of patients with severe PIH, it has certain importance for further study on the pathogenesis of severe PIH.
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