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  • Title: Metabolic studies with the nonnutritive sweetener cycloheptylsulfamate.
    Author: Benson GA, Spillane WJ.
    Journal: J Pharm Sci; 1977 Jun; 66(6):881-3. PubMed ID: 874797.
    Abstract:
    The nonnutritive sweetener cycloheptylsulfamate was administered orally to rabbits and rats. The urine of each species was separately collected for 3 days and examined for the metabolites cycloheptylamine, cycloheptanone, and cycloheptanol and for cycloheptylsulfamate. A previously tested GLC method was adapted for the determination of the metabolites. Cycloheptylsulfamate was assayed by hydrolysis and subsequent measurement of the absorbance of the product formed (lambdamax=489 nm) by the liberated amine with p-benzoquinone. The conversions to the metabolites were 0.276, 0.390, and 0.170%, respectively, in rabbits and 0.064, 0.022, and 0.017%, respectively, in rats.
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