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  • Title: Immune response gene control of determinant selection. II. Genetic control of the murine T lymphocyte proliferative response to insulin.
    Author: Rosenwasser LJ, Barcinski MA, Schwartz RH, Rosenthal AS.
    Journal: J Immunol; 1979 Jul; 123(1):471-6. PubMed ID: 87482.
    Abstract:
    The genetic control of the murine T cell proliferative response to insulin was examined. It was found for two responder strains of mice that each recognizes a different determinant on the insulin molecule. H-2b mice recognize a determinant in the A chain loop of insulin whereas H-2d mice recognize a determinant that resides in the B chain, possibly in the last eight amino acids. Using H-2 recombinant strains of mice, the location of Ir gene control of the response to both determinants was mapped to the K region and/or I-A subregion of H-2. The possibility of non-MHC regulation of MHC-controlled immune responses is suggested by studies of recombinant inbred strains of mice.
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