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Title: Changes in the amplitude of the N30 frontal component of SEPs during apomorphine test in parkinsonian patients. Author: de Mari M, Margari L, Lamberti P, Iliceto G, Ferrari E. Journal: J Neural Transm Suppl; 1995; 45():171-6. PubMed ID: 8748623. Abstract: Somatosensory evoked potentials (SEPs) to median nerve stimulation have been performed before and after apomorphine-test in 10 parkinsonian patients. Latency and amplitude of the P14-N20 parietal complex and of the P20-N30 frontal complex were evaluated. The N30 amplitude was significantly reduced before apomorphine administration (p < 0.001) with a consequent increase of the N20/N30 amplitude ratio (p < 0.001). Eight patients clinically improved after Apomorphine. Following Apomorphine there was no change in the amplitude of the parietal complex P14-N20. On the other hand the frontal complex P20-N30 showed a significant amplitude potentiation (p < 0.005), with a reduction of the N20/ N30 amplitude ratio (ns). This finding was almost constant among the 8 responder patients. These results suggest the utility of combining clinical and neurophysiological data to assess the responsiveness to dopaminergic treatment.[Abstract] [Full Text] [Related] [New Search]