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  • Title: Effect of intratympanically administered gentamicin on hearing and tinnitus in Menière's disease.
    Author: Kaasinen S, Pyykkö I, Ishizaki H, Aalto H.
    Journal: Acta Otolaryngol Suppl; 1995; 520 Pt 1():184-5. PubMed ID: 8749114.
    Abstract:
    We have examined the effect of intratympanic gentamicin on hearing and tinnitus in 69 patients with intractable Menière's disease. Tinnitus was scored from 1 to 4 depending on its severity. The mean pure tone audiometry level before treatment was 57.5 dB and 1 year after treatment 63.5 dB Five subjects became deaf in the treated ear, and in 13 subjects hearing loss was > 10 dB and in 21 subjects 0 10 dB. In 25 subjects significant improvement (> 10 dB) was gained, and in 5 patients. Tinnitus was significantly reduced after treatment with gentamicin. A total of 66 patients had tinnitus before treatment and tinnitus relief was rated as good. Four percent of the subjects had no tinnitus, 30% had slight tinnitus. 27% moderate tinnitus. 18% severe and 8% handicapping tinnitus.
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