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  • Title: Crystallization of the complex of human IFN-gamma and the extracellular domain of the IFN-gamma receptor.
    Author: Chène C, Fountoulakis M, Döbeli H, D'Arcy B, Winkler F, D'Arcy A.
    Journal: Proteins; 1995 Dec; 23(4):591-4. PubMed ID: 8749856.
    Abstract:
    A complex of human interferon-gamma (IFN-gamma) with the soluble extracellular domain of the IFN-gamma receptor alpha-chain (IFN-gamma-R) has been crystallised. Crystals of the complex were grown using PEG 4000 as the precipitating agent in the presence of beta-octyl glucoside. The receptor-ligand complex crystallizes in a monoclinic space group and diffracts to about 3.0 A resolution. Isomorphous crystals have been obtained with complex containing selenomethionine and cysteine mutants of IFN-gamma, which may facilitate the ongoing X-ray structure determination.
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