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  • Title: Synchronous patchy pattern of gene expression for adenylyl cyclase and phosphodiesterase but discrete expression for G-protein in developing rat striatum.
    Author: Sakagami H, Sawamura Y, Kondo H.
    Journal: Brain Res Mol Brain Res; 1995 Nov; 33(2):185-91. PubMed ID: 8750876.
    Abstract:
    The ontogeny of the gene expression for striatal adenylyl cyclase (AC), 63 kDa calmodulin-dependent phosphodiesterase (63 kDa CaM-PDE) and olfactory G-protein (Golf), all of which are expressed predominantly in the striatum, was studied by in situ hybridization histochemistry. In the peri- and early postnatal striatum, the gene expression for striatal AC and 63 kDa CaM-PDE showed a patchy pattern corresponding to the striatal patchy compartments enriched in several molecules involved in cAMP-signaling system including DARPP-32 (a dopamine and cyclic adenosine 3':5'-monophosphate-regulated phosphoprotein with an apparent M(r) of 32,000). On the other hand, Golf showed a homogeneous expression pattern throughout the striatal development. The present finding suggests that the gene expression for the three molecules directly involved in the cAMP-generating and degrading system is differentially regulated during the striatal development.
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