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  • Title: [The molecular mechanisms of the action of the radioprotector indometafen. The biosynthetic and bioenergetic aspects].
    Author: Chernov GA, Sharygin VL, Pulatova MK, Sharf VG, Borovkov MV, Shliakova TG, Khristianovich DS, Mitrokhin IuI, Todorov IN.
    Journal: Izv Akad Nauk Ser Biol; 1996; (3):282-91. PubMed ID: 8755028.
    Abstract:
    It was shown that indomethaphen (IM) is capable of stimulation of the synthesis of DNA, RNA, and protein precursors in mice. The IM-induced elevated level of the ribonucleotide reductase activity and, hence, deoxyribonucleotide pool in the spleen at the moment of irradiation and during the early postradiation period provides for complete DNA repair. As a result, the damaging effect of ionizing irradiation is weakened. At later stages (2-20 days) IM activates protein and DNA synthesis leading to the recovery of the ribonucleotide reductase activity in the spleen, on increased content of Fe3(+)-transferrin, cytochrome-c-oxidase, and ferrosulfuric components of the mitochondrial electron transport chain, and increased potential of the detoxication system due to the elevated content of cytochrome P-450. IM stimulates ATP synthesis. Thus, IM enhances compensatory-restorative reactions of the cell systems, more pronounced in the spleen than in the liver.
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