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  • Title: Oral versus intravenous high-dose steroid treatment of renal allograft rejection. The big shot or not?
    Author: Gray D, Shepherd H, Daar A, Oliver DO, Morris PJ.
    Journal: Lancet; 1978 Jan 21; 1(8056):117-8. PubMed ID: 87551.
    Abstract:
    50 episodes of renal allograft rejection were treated by oral prednisolone and 49 by intravenous methylprednisolone. Both treatments achieved reversal of rejection in approximately 60% of episodes. Morbidity-rates, as assessed by hypertension, oliguria, fluid retention, and infection, tended to be greater after oral treatment. When the results were reexamined for accelerated, acute, and chronic rejection episodes the only difference demonstrated was an increased frequency of fluid retention in patients treated by oral prednisolone for an acute rejection episode. There was no evidence that intravenous methylprednisolone was nephrotoxic.
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