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  • Title: Effects of gypenosides on cellular immunity of gamma-ray-irradiated mice.
    Author: Hau DM, Feng Y, Chen WC, Lin IH, Chen KT, Lin SS, Wang MI.
    Journal: Chin Med J (Engl); 1996 Feb; 109(2):143-6. PubMed ID: 8758340.
    Abstract:
    OBJECTIVE: To investigate the effects of gypenosides (Gs) on cellular immunocompetence in the gamma-ray-irradiated mice. MATERIALS AND METHODS: Tested mice of ICR strain were treated continuously with Gs for 10 days before or after 4 Gy gamma-irradiation. Body weight and splenic weight of mice were measured. The blastogenic response of splenocytes to mitogens, such as PHA, Con A and LPS were also detected. The cellular immunocompetence was measured by 3H-thymidine incorporation in each tested mouse. RESULTS: Body weight as well as splenic weight decreased in gamma-ray-irradiated mice. The blastogenic responses of splenocytes to mitogens were inhibited after gamma-ray irradiation. To treat with Gs was effective to enhance the recovery of body weight, splenic weight and immunocompetence in gamma-ray-irradiated mice from radiation damage. CONCLUSIONS: Four Gy gamma-ray irradiation could decrease splenic weight and cellular immunocompetence of mice. Gs could help the recovery of the splenic weight and cellular immunocompetence in gamma-ray-irradiated mice.
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