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  • Title: The first one hundred AIDS cases in Hong Kong.
    Author: Lee SS, Lo YC, Wong KH.
    Journal: Chin Med J (Engl); 1996 Jan; 109(1):70-6. PubMed ID: 8758375.
    Abstract:
    OBJECTIVE: To study the clinical and epidemiological characteristics of the first 100 reported AIDS cases in Hong Kong. PATIENTS AND METHODS: The case records of the first 100 AIDS cases reported to the Department of Health were retrieved. An analysis was made on their demographic data, clinical and immunologic profile, treatment received as well as mortality. RESULTS: The AIDS patients were reported over a ten-year period, from February 1985 to March 1994. The majority of them were male, Chinese and between the age of 20 and 49. More than 80% acquired HIV via sexual contact. The most common primary AIDS- defining illness was Pneumocystis carinii pneumonia (PCP), which occurred in 46 patients. Eight episodes of Penicillium marneffei infection have been recorded. Fifty-nine patients have received antiretroviral therapy whereas PCP prophylaxis was given to 47 patients. The mean CD4 count at HIV and AIDS diagnosis was 394/microliters and 121 /microliters respectively. Sixty-seven patients were known to have died at the time of the analysis. PCP was the most common cause of death, accounting for over one-fifth of the cases. The median survival after AIDS diagnosis was less than 2 months for cases reported in 1985-1987 and over 15 months for those of 1990-1991. CONCLUSION: Pneumocystis carinii pneumonia was the most common initial AIDS-defining disease and cause of death in Hong Kong. Survival of the patients has gradually improved over the past few years. In Hong Kong, the reporting of HIV infection and AIDS cases is not mandated by law. A voluntary reporting system, however, has been in place since early 1985 to facilitate the collection of epidemiological data on HIV/AIDS. The authors reviewed the records of the first 100 AIDS cases reported to the Department of Health in Hong Kong to learn about their clinical and epidemiological characteristics. The AIDS patients were reported between February 1985 and March 1994, with the majority being Chinese, male, and age 20-49 years. More than 80% acquired HIV through sexual contact. Occurring in 46 patients, pneumocystis carinii pneumonia (PCP) was the most common primary AIDS-defining illness. Eight episodes of Penicillium marneffei infection were recorded. 59 patients received antiretroviral therapy and PCP prophylaxis was given to 47 patients. Mean CD4 counts at HIV and AIDS diagnosis were 394 and 121 per mcl, respectively. 67 patients were known to have died at the time of the study, with PCP being the most common cause of death, accounting for more than 20% of mortality. The median survival period after diagnosis of AIDS was 2 months for cases reported in 1985-87 and more than 15 months for those of 1990-91.
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