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  • Title: [Glutamine dipeptide enriched nutritional solutions attenuate bacterial translocation in rats after 60% intestinal resections].
    Author: Bai M, Jiang Z, Ma Y.
    Journal: Zhonghua Yi Xue Za Zhi; 1996 Feb; 76(2):116-9. PubMed ID: 8758443.
    Abstract:
    OBJECTIVE: To investigate the effects of alanyl-glutamine dipeptide (Ala-Gln) enriched parenteral nutrition solution on intestinal mucosa or gut barrier since traditional parenteral nutrition leads to bacterial translocation. METHODS: The moderate operation stress was induced by 60% resection of small intestine. Qualified rats distributed in three groups: Chow group (n = 10) received standard rat chow, PN group (n = 10) received traditional parenteral nutrition solution only, and Ala-Gln group (n = 10) received glutamine dipeptide enriched nutritional solutions (3% Ala-Gln). Rats were maintained on their respective diets for 7 days. RESULTS: Chow group and Ala-Gln group maintained serum glutamine concentration, villus height and mucosal thickness. The bacterial translocation rate in Chow group and Ala-Gln group was 20% and in PN group 70%. CONCLUSION: Results demonstrate that Ala-Gln enriched nutritional solutions maintain intestinal adaptation and gut barrier function after massive intestinal resection.
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