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  • Title: [Effects of oxygen free radicals on myocardial alpha 1-adrenoceptor and its subtypes in rat].
    Author: Gong HB, Han QD.
    Journal: Sheng Li Xue Bao; 1996 Feb; 48(1):48-52. PubMed ID: 8758690.
    Abstract:
    The effects of oxygen free radicals on myocardial alpha 1-adrenoceptor and its subtypes and beta-adrenoceptor were observed by the method of radioligand binding assay in rat. The experiments showed: (1) .OH and O??? reduced the Bmax of alpha 1-adrenoceptors binding to 125IBE2254 by 55% and 36%, respectively. (2) The KI values of alpha 1-adrenoceptors were increased by .OH (by 171%), but not by O2-. (3) Both .OH and O2-. increased the ratio of alpha 1A vs alpha 1B subtypes. (4) beta-adrenoceptors were not changed by either .OH or O2-. (5) Oxygen free radical scavengers mannitol and superoxide dismutase were capable of preventing the changes of alpha 1-adrenoceptor and its subtypes induced by oxygen free radicals. The above results suggest that oxygen free radicals can reduce the number and affinity of myocardial alpha 1-adrenoceptors, of which the alpha 1B subtype is more accessible to the changes.
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