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  • Title: [Combination chemotherapy of 5-fluorouracil and nitrocaphane for the treatment of malignant trophoblastic tumor].
    Author: Ju L, Wang Y, Qu D.
    Journal: Zhonghua Fu Chan Ke Za Zhi; 1996 Apr; 31(4):212-5. PubMed ID: 8758775.
    Abstract:
    OBJECTIVE: To evaluate the effectiveness, side effects and long term result of combination protocol of 5-fluorouracil (5-FU) and nitrocaphane (AT1258) on patients with malignant trophoblastic tumor. METHODS: The chart and follow up data of 166 patients treated from 1979 to 1988 in Liaoning Province Tumor Hospital were reviewed. 136 invasive mole and 30 choriocarcinoma were treated by a 5-FU and AT1258 combined protocol. Their immediate treatment results, side effects and long-term follow-ups were retrospectively analysed. RESULTS: The complete remission rate of invasion mole was 100.0% and choriocarcinoma 86.7%. The accumulative 5 and 10 year's survival rate for invasive mole were 100.0% and 99.3%, while 85.8% and 85.8% for choriocarcinoma. None of this group died of side effects or complication. CONCLUSION: 5-FU and AT1258 combination chemotherapy may be a protocol of choice in the treatment of malignant trophoblastic tumor.
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