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  • Title: [Influence of microiontophoretic morphine on nociceptive responses of Pf neurons after lesion of SmI].
    Author: Zheng X, Chen Z, Shi H, Xu W.
    Journal: Zhen Ci Yan Jiu; 1995; 20(3):18-21. PubMed ID: 8758822.
    Abstract:
    Neuronal responses in thalamic nucleus parafasciculus (Pf) to microiontophoretic morphine were examined in 20 wistar rats after lesion of SmI. Extracellular recordings were made with five-barreled glass microelectrodes. The results showed that the spontaneous responses of Pf neurons were not statistically changed (n = 11, P > 0.05), but their nociceptive responses were attenuated at 0-8 minutes after iontophoretic morphine (n = 11, P < 0.05). There were statistically significant differences in nociceptive responses between morphine and saline groups at 0-8 minutes after iontophoresis. The results suggest that morphine may be involved in corticofugal modulation of nociceptive responses in thalamic Pf neurons.
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