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  • Title: Motor nerve sprouting induction by a nerve explant in normal and vitamin E-deficient rats.
    Author: Cuppini C, Ambrogini P, Buffi O, Cuppini R, Ciaroni S, Cecchini T.
    Journal: Ital J Anat Embryol; 1995; 100(3):135-46. PubMed ID: 8760482.
    Abstract:
    Sprouting induction by a peripheral degenerating nerve has been evaluated in normal and vitamin E-deficient rats. A piece of sural nerve was grafted close to the peroneal nerve of the same animal: at one and two months after grafting thin unmyelinated axons were visible in the graft and they were sometimes functionally active; when nerve explant was frozen before grafting, sprouting induction did not take place either in controls or in vitamin E-deficient animals. No difference was noted in sprouting induction between the two groups, while degeneration showed a different time course. Some hypotheses of possible stimuli of sprouting induction are discussed.
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