These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Effect of testosterone on carbonic anhydrase and MG(2+)-dependent HCO3-stimulated ATPase activities in rat kidney: comparison with estradiol effect.
    Author: Suzuki S, Yoshida J, Takahashi T.
    Journal: Comp Biochem Physiol C Pharmacol Toxicol Endocrinol; 1996 Jun; 114(2):105-12. PubMed ID: 8760605.
    Abstract:
    Effects of testosterone administration (TP; 1-3 mg/kg body weight, S.C., once daily for 7 days) on the cytosol carbonic anhydrase (CA) and tubular brush border Mg(2+)-dependent HCO3(-)-stimulated ATPase (Mg(2+)-HCO3(-)-ATPase) activities of normal and castrated male and female rat kidney were compared with estradiol (E2) effects. TP decreased kidney CA activity in a dose-dependent manner in all four animal conditions, and negative correlations were observed between cytosol CA activity and serum testosterone concentration. However, brush border Mg(2+)-HCO3(-)-ATPase activity was not affected by testosterone. Orchiectomy increased only CA activity and its value recovered to normal levels by 3 mg/kg TP replacement, whereas Mg(2+)-HCO3(-)-ATPase activity did not change. In the previous study, on the other hand, E2 administration activated both kidney enzymes in normal male rats and only Mg(2+)-HCO3(-)-ATPase in normal female rats. Testosterone and E2 conversely affected kidney CA activity in male rats. These facts suggest that the cytosol CA may control kidney functions on H+ and HCO3- metabolism under the balance of both sex hormones in the living body.
    [Abstract] [Full Text] [Related] [New Search]