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  • Title: [Nephrotic syndrome complicating treatment with interferon alpha].
    Author: Dhib M, Bakhache E, Postec E, Vanrenterghem B, Le Roy F, Azar R, François A, Boldron A, Amaria R, Ozenne G, Hermelin A.
    Journal: Presse Med; 1996 Jun 29; 25(23):1066-8. PubMed ID: 8760627.
    Abstract:
    UNLABELLED: We report two cases of nephrotic syndrome with minimal glomerular change complicating alpha-interferon therapy. CASE REPORTS: The first patient was a 60-year-old man with Waldenström's disease who was given 1 million units of alpha-interferon three times a week for 22 months. Acute renal failure developed when a second protocol was started. Renal biopsy revealed intraglomerular deposits and no cellular proliferation. Total remission could not be achieved with corticosteroids. The second case was a 46-year-old man given high dose alpha-interferon (15 million units 3 times a week) for lymph node metastasis of a malignant melanoma. A nephrotic syndrome without renal failure developed during the third month of treatment. Minimal glomerular involvement was seen. Symptomatic treatment led to resolution of the nephrotic syndrome. DISCUSSION: Nine other cases of nephrotic syndrome complicating alpha-interferon therapy have been reported in the literature.
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