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  • Title: Treatment of mixed cryoglobulinemia with recombinant interferon alpha and adjuvant therapies. A prospective study on 20 patients.
    Author: Cohen P, Nguyen QT, Dény P, Ferrière F, Roulot D, Lortholary O, Jarrousse B, Danon F, Barrier JH, Ceccaldi J, Constans J, Crickx B, Fiessinger JN, Hachulla E, Jaccard A, Seligmann M, Kazatchkine M, Laroche L, Subra JF, Turlure P, Guillevin L.
    Journal: Ann Med Interne (Paris); 1996; 147(2):81-6. PubMed ID: 8760684.
    Abstract:
    In order to evaluate the efficacy of interferon alpha (IFNa) in mixed cryoglobulinemia (MC), a prospective multicenter clinical trial was conduced in April 1992. It consisted of treating 20 clinically symptomatic MC patients with IFNa for 26 weeks. Hepatitis C virus (HCV) infection was detected in 16 patients. A complete or partial clinical remission was obtained in 12 patients (60%). Eleven of these 12 responders (91.6%) experienced a clinical relapse less than 12 months after the end of therapy. Side effects were noted in 10 patients (50%). It was concluded that subcutaneously administered IFNa does not provide long-term remission.
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