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  • Title: [The effects of single administration of kainic acid on cellular signal transmission pathway and susceptibility to seizure].
    Author: Gao X, Zhang WQ, Hong JS.
    Journal: Sheng Li Xue Bao; 1995 Dec; 47(6):589-96. PubMed ID: 8762450.
    Abstract:
    In this study, Sprague-Dawley (S.D.) rats were pretreated with kainic acid (KA, 10 mg/kg, i. sc.) 72 days before either deep prepyriform cortex (DPC) kindling or injection of the same dose of KA. The results showed that such pretreatment accelerated the process of kindling, and the KA-induced seizures appeared more severe in behaviours. c-Fos-immunoreactivity (c-Fos-ir) was used to demonstrate the neuronal activity in central nervous system during the provocative dose of KA-induced seizure, as comparing with the control which received normal saline of KA 72 days ago. The results indicated that, the transmission pathways in two groups were just the same; but the time courses of c-fos and c-jun expression in KA pretreated group were accelerated asynchronously; and the synthesis of the proenkephalin mRNA in the Ent was apparently up-regulated. It is suggested that, the long-lasting increase in susceptibility to seizure induced by a single administration of KA may be related to the acceleration of the expression of c-fos/jun and the early onset of the expression of proenkephalin mRNA.
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