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  • Title: [Effects of (-) SPD and (-) THP on the firing of noradrenergic neurons in locus coeruleus].
    Author: Wu JH, Jin GZ.
    Journal: Sheng Li Xue Bao; 1995 Dec; 47(6):601-4. PubMed ID: 8762452.
    Abstract:
    The effects of (-) SPD and (-) THP on the noradrenergic neurons in rat locus coeruleus were investigated by recording the in vivo spontaneous firing. It was found that (-) SPD could increase the firing frequency of the NE neurons via antagonistic action on alpha 2 autoreceptors in a dose-dependent manner, while alpha 2 receptor agonist clonidine exerted an inhibitory effect. (-) THP induced inhibitory firing of the neurons, however, irreversible.
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