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  • Title: Impact of theophylline use in Wolff-Parkinson-White syndrome.
    Author: Agwunobi J, Abedin M, Young M, Beeram M, Sinkford S.
    Journal: J Natl Med Assoc; 1996 Jul; 88(7):450-2. PubMed ID: 8764528.
    Abstract:
    Methylxanthine use in the treatment of apnea of prematurity is well documented. This drug is avoided in patients with aberrant pathways of conduction such as Wolff-Parkinson-White syndrome. In theory, methylxanthines enhance precipitation and exacerbation of tachyarrhythmias to which these patients are predisposed. This article reports a case of Wolff-Parkinson-White syndrome in a preterm neonate with severe apneic episodes in which methylxanthines were used. However, no adverse effects on cardiac rate or rhythm were encountered.
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