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  • Title: Synthesis and SAR study of imidazo[2,1-b]benzothiazole acids and some related compounds with anti-inflammatory and analgesic activities.
    Author: Palagiano F, Arenare L, De Caprariis P, Grandolini G, Ambrogi V, Perioli L, Filippelli W, Falcone G, Rossi F.
    Journal: Farmaco; 1996 Jul; 51(7):483-91. PubMed ID: 8765671.
    Abstract:
    Some (un)substituted imidazo[2,1-b]benzothiazole carboxylic or acetic acids and some related compounds, i.e. imidazo[2,1-b]naphthol[2,1-d]thiazole, 4H-imidazo[2,1-c][1,4]benzothiazine, 4,5-dihydroimidazo[2,1-d][1,5]benzothiazepine carboxylic and acetic acids were synthesized and tested in vivo in order to study the structure-activity relationships (SAR) of their antiinflammatory and analgesic activities. Pharmacological assays confirmed the interest of this class of compounds as potential antiinflammatory and analgesic drugs with low side effects.
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