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  • Title: [Ifosfamide in pediatric malignancy--experiences in the Northern Israel Oncology Center].
    Author: Roguin A, Ben Arush MW, Higasi A, Kuten A.
    Journal: Harefuah; 1996 Apr 15; 130(8):511-4, 584. PubMed ID: 8765870.
    Abstract:
    The records of 46 children treated with ifosfamide between 1987-1994 were analyzed. 24 received the drug as first-line chemotherapy in combination with vincristine and etoposide or with adriamycin, vincristine and cyclophosphamide. Complete remission was achieved in 8/10 children with soft tissue sarcoma, 7/8 with Ewing's sarcoma, 2/2 with ovarian carcinoma and 2/2 with clear cell sarcoma of the kidney. 22 children in whom first-line chemotherapy failed were then treated with ifosfamide and etoposide. Complete remission was achieved in 7/10 children with osteosarcoma, 1/2 with Wilms' tumor and 1/3 with neuroblastoma.
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