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  • Title: Synthesis and antimicrobial activity of some new piperidinyl benzimidazoles.
    Author: Kuş C, Göker H, Ayhan G, Ertan R, Altanlar N, Akin A.
    Journal: Farmaco; 1996 Jun; 51(6):413-7. PubMed ID: 8766224.
    Abstract:
    A series of 2-(4-methylpiperidin-1-yl)-1,5(6)-disubstituted-1H-benzimidazoles (1-18) were prepared through the reaction of 2-chloro (or 2-chloromethyl)-1H-benzimidazole derivatives with 4-methylpiperidine. For the preparation of the individual isomers, compounds 7, 9 and 18 were synthesized by a multistep procedure. The prepared compounds were screened for their in vitro antibacterial and antifungal activities. Compound 3 and 4 exhibited the best antifungal activity.
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