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  • Title: Pyrazolo[1,5-a]pyrido[3,4-e]pyrimidin-6-ones. I. Synthesis and in vitro antimicrobial evaluation.
    Author: Bruni F, Selleri S, Costanzo A, Guerrini G, Casilli ML, Sacco C, Donato R.
    Journal: Farmaco; 1996 Jun; 51(6):451-5. PubMed ID: 8766231.
    Abstract:
    A series of pyrazolo[1,5-a]pyrido[3,4-e]pyrimidin-6-ones (9-36) was prepared by a simple synthetic procedure based on the reaction of ethyl 7-dimethylaminovinyl pyrazolo[1,5-a]pyrimidin-6-carboxylates (1-8) and reagents (a-n) containing a primary amino group. When this set of compounds was subjected to "in vitro" antimicrobial screening, it showed no significant activity.
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