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  • Title: Increased hepatic copper concentration in Indian childhood cirrhosis.
    Author: Tanner MS, Portmann B, Mowat AP, Williams R, Pandit AN, Mills CF, Bremner I.
    Journal: Lancet; 1979 Jun 09; 1(8128):1203-5. PubMed ID: 87675.
    Abstract:
    19 Indian children with liver disease were studied. 5 in whom a clinical and histological diagnosis of Indian Childhood Cirrhosis was made had massive orcein-staining deposits in liver cells. The hepatic copper content in these 5 cases was strikingly high (1389 microgram/g dry tissue, range 1045--2303) the normal range being 15--55 microgram/g. Of the other 14 cases, only 2 had hepatic copper levels above normal (170 and 262 microgram/g.) This high hepatic copper concentration may be caused by excessive copper ingestion or an abnormality of copper metabolism.
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