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  • Title: [Balanced beta--alpha-blocker treatment with carvedilol in mild-moderate arterial hypertension].
    Author: Perocchio M, Gigli G, Barra M, Sacchetti R, Vallebona A, Rosolen GA, Orlandi S.
    Journal: Minerva Cardioangiol; 1996 Mar; 44(3):115-21. PubMed ID: 8767610.
    Abstract:
    The search for the ideal antihypertensive drug is ongoing. Carvedilol is a new beta-adrenoceptor antagonist which also causes peripheral vasodilation primarily via alpha 1-adrenergic blockade. Twenty patients with mild to moderate essential hypertension and previous intolerance and side effects to other antihypertensive drugs were studied. After initial baseline assessment, patients received 25 mg carvedilol orally q.d. The treatment lasted 60 days. In our study carvedilol was well tolerated and no important side effect was recorded. Blood pressure decreased significantly to normal values, without orthostatic blood pressure decreases. Heart rate decreased significantly too, but no significant bradycardia was induced. No negative effects on serum lipids and no clinical evidence of increase in peripheral resistance were observed. Ventricular arrhythmia on Holter monitoring were significantly reduced after treatment with carvedilol.
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