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  • Title: Impact of sar and agr on methicillin resistance in Staphylococcus aureus.
    Author: Píriz Durán S, Kayser FH, Berger-Bächi B.
    Journal: FEMS Microbiol Lett; 1996 Aug 01; 141(2-3):255-60. PubMed ID: 8768531.
    Abstract:
    The global regulators agr and sar control expression of cell wall and extracellular proteins. Inactivation of either sar and/or agr in a typical heterogeneously methicillin-resistant Staphylococcus aureus resulted in a small but reproducible decrease in the number of cells in the subpopulation expressing high methicillin resistance. The amount of low affinity penicillin-binding protein PBP2', the prerequisite for methicillin resistance, was apparently not affected, however, a reduction in PBP1 and PBP3 production was observed, suggesting that these resident PBPs of the cells might be involved somehow together with PBP2' in high level methicillin resistance.
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