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  • Title: Prolonged survival of rat hepatic allografts pretreated with a single donor-specific blood transfusion: the distribution of donor cells expressing class I major histocompatibility complex antigens in the recipient.
    Author: Yamaguchi Y, Goto M, Makino Y, Kikuchi N, Hamaguchi H, Hisama N, Miyanari N, Mori K, Ogawa M.
    Journal: J Surg Res; 1996 Feb 15; 61(1):23-9. PubMed ID: 8769937.
    Abstract:
    We previously reported that a pretransplant transfusion of either ACI strain rat donor blood or PVG.r1 strain blood, which shares only the RT1.A class I major histocompatibility complex (MHC) region with an ACI donor, significantly prolonged the survival of ACI-to-LEW rat hepatic allografts, suggesting that the class I MHC antigens can be immunosuppressive in rat hepatic allografts. The distribution of the donor cells expressing RT1.Aa class I MHC antigens in the recipients was investigated using a MN4-91-6 mouse anti-rat class I (RT1.Aa) MHC monoclonal antibody. The donor class I MHC-positive cells accumulated mainly in the splenic white pulp and lymph nodes at 12 and 24 hr after blood transfusion, while very few cells were seen in the thymus, liver, lungs, and kidneys. The number of cells began to decrease in the splenic white pulp and lymph nodes at 24 hr after transfusion. This may indicate the destruction of donor cells by the recipient cells. Within 48 hr after transfusion, most cells disappeared from the recipient tissue. In an attempt to study the role of the spleen in inducing immunological unresponsiveness, a splenectomy was performed at the time of transplantation and this abrogated the prolongation of hepatic allograft survival in the recipients which received the donor blood. These findings suggest that the presence of class I MHC-positive cells in the splenic white pulp, a T-dependent area, may play an important role in inducing immunological unresponsiveness.
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