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  • Title: Role of intercellular adhesion molecule-1 in antigen-induced lung inflammation in brown Norway rats.
    Author: Richards IM, Kolbasa KP, Winterrowd GE, Hatfield CA, Vonderfecht SL, Fidler SF, Griffin RL, Brashler JR, Krzesicki RF, Lane CL, Anderson DC, Sly LM, Staite ND, Chin JE.
    Journal: Am J Physiol; 1996 Aug; 271(2 Pt 1):L267-76. PubMed ID: 8770066.
    Abstract:
    We investigated the involvement of intercellular adhesion molecule-1 (ICAM-1; CD54) in ovalbumin (OA) antigen-induced lung inflammation in sensitized Brown Norway (BN) rats by using flow cytometry and in vivo treatment with a murine monoclonal antibody (MAb), 1A29, directed against rat ICAM-1. OA-challenge induced an eosinophil and lymphocyte-rich accumulation of leukocytes into the airway lumen. Between 75 and 90% of the T cells in bronchoalveolar lavage (BAL) fluid after challenge expressed CD54 and CD11a and were of the memory phenotype. 1A29 treatment produced dose-related increases in circulating 1A29 and blood neutrophils. In the BAL fluid of 1A29-treated animals, significant (P < 0.05) reductions in the numbers of eosinophils and lymphocytes, but not neutrophils or alveolar macrophages, were observed in association with a reduced inflammatory pathology in lung tissue. 1A29 administration reduced the number of detectable ICAM-1 binding sites on T cells in peripheral blood and BAL fluid examined ex vivo by flow cytometry. We conclude that ICAM-1 is critically important for the antigen-specific recruitment of eosinophils and lymphocytes into the lungs.
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