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  • Title: Mutations Modulating Raf signaling in Drosophila eye development.
    Author: Dickson BJ, van der Straten A, Dominguez M, Hafen E.
    Journal: Genetics; 1996 Jan; 142(1):163-71. PubMed ID: 8770593.
    Abstract:
    The R7 fate is specified during Drosophila eye development by an inductive signal transduced intracellularly via the Raf kinase. We have performed a genetic screen for dominant mutations that alter the efficiency with which cells respond to a constitutively activated Raf kinase. Such mutations may affect genes involved in signal transduction downstream of Raf. We have isolated 44 mutations that define eight genes. One of these encodes a mitogen-activated protein kinase homologue: another is a putative target gene of this signaling pathway. We present the results of this screen in detail, as well as a preliminary genetic analysis of the six loci still to be characterized molecularly.
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