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  • Title: Inhibition of experimental lactational mammary gland growth in the rat with exogenous estrogen and progesterone.
    Author: Ferreri LF, Griffith DR.
    Journal: Proc Soc Exp Biol Med; 1977 Jul; 155(3):429-32. PubMed ID: 877143.
    Abstract:
    To determine if the combination of estrogen and progesterone during pregnancy inhibits only the secretory capacity of the mammary gland or if it also inhibits the mitotic activity associated with lactogenesis, 113 virgin female Sprague-Dawley rats were ovariectomized and injected daily for 20 days with 2 mcg of 17beta-estradiol-3 benzoate and 6 mg of progesterone (EP). Then in 4 groups daily, injections were given of either cortisol (C), prolactin (L), growth hormone (G), or a combination of all 3 hormones, for 3 days following the last injection of EP. In another series of 4 groups, the injections of EP were continued along with the above 3 hormones. The structural and functional status of the mammary glands were estimated by measurement of DNA, RNA, and nitrogen content. Details of methods used are given. Only the group treated with C showed the maximum lactational activity with significant elevations in DNA, RNA, and nitrogen content of the mammary glands. When EP was given along with C, G, and L, all hormonally induced increases in DNA, RNA, and nitrogen were inhibited. Results were thought to indicate that, in the rat, levels of EP during normal pregnancy hold milk secretion in abeyance until parturition and also block the particular type of mitotic growth phase associated with early lactation.
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