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  • Title: Continuous subcutaneous insulin infusion: improved blood-glucose and intermediary-metabolite control in diabetics.
    Author: Pickup JC, Keen H, Parsons JA, Alberti KG, Rowe AS.
    Journal: Lancet; 1979 Jun 16; 1(8129):1255-7. PubMed ID: 87724.
    Abstract:
    Blood-levels of glucose and the major intermediary metabolites, lactate, pyruvate, 3-hydroxybutyrate, and alanine, were measured in 7 insulin-dependent diabetics during 24 h of continuous subcutaneous insulin infusion (C.S.I.I.) from a portable dual-rate syringe pump. Results were compared with metabolic profiles during the patients' conventional insulin treatment and with those of 17 non-diabetics. The mean 24 h plasma-glucose during C.S.I.I. was not significantly different from that in non-diabetics. During infusion blood concentrations of lactate, pyruvate, 3-hydroxybutyrate, and alanine were also close to those in the non-diabetic state. Thus, C.S.I.I. provides strict control not only of blood-glucose but also of major metabolites, an essential prerequisite for investigating the influence of good metabolic control on diabetic microangiography.
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