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  • Title: Nifedipine in migraine and tension headache: a randomised double blind crossover study.
    Author: Shukla R, Garg RK, Nag D, Ahuja RC.
    Journal: J Assoc Physicians India; 1995 Nov; 43(11):770-2. PubMed ID: 8773038.
    Abstract:
    Nifedipine was evaluated in the prophylaxis of 28 patients each of migraine and tension headache using a double blind cross over design with random allocation to drug or placebo group. The duration of the trial was 3 months with a 2 week run-in period and 2 week wash-oat period separating two treatment periods of 4 weeks each. A satisfactory response was obtained in 71.4% of migraineurs (p < 0.001) and 28.6% of patients with tension headache (p = N.S). Minor side effects were observed in 5 patients. Nifedipine is a useful agent for the management of migraine as it reduces frequency and severity of pain but the drug cannot be recommended for tension headache.
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