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  • Title: Genetic epidemiology of the three predominant abnormal hemoglobins in India.
    Author: Balgir RS.
    Journal: J Assoc Physicians India; 1996 Jan; 44(1):25-8. PubMed ID: 8773089.
    Abstract:
    Hemoglobinopathies in India are Important public health problems. Of the several abnormal of hemoglobin molecules, there are three variants, viz. Sickle cell, hemoglobin E and hemoglobin D which are predominantly prevalent in India. The cumulative gene frequencies of these hemoglobins have been found to be 5.35% in India. The average gene frequency of sickle cell and hemoglobin D in India has been observed to be 4.3% and 0.86%, respectively. In the North Eastern region of India, the gene frequency of hemoglobin E is 10.9%. Gene frequencies and spatial distribution of the predominant abnormal hemoglobins in India have been discussed in variance with the previous generalisations.
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