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  • Title: Microinjection of NMDA antagonist into the NTS of conscious rats blocks the Bezold-Jarisch reflex.
    Author: Chianca DA, Machado BH.
    Journal: Brain Res; 1996 Apr 29; 718(1-2):185-8. PubMed ID: 8773784.
    Abstract:
    The purpose of the present study was to evaluate whether or not cardiovagal excitatory and sympatho-inhibitory pathways of the Bezold-Jarisch reflex at the NTS level were mediated by NMDA receptors. The Bezold-Jarisch reflex was activated by intravenous (i.v.) injection of serotonin in conscious rats before and after microinjection of phosphonovaleric acid (AP-5) a selective NMDA antagonist, into the NTS. The Bezold-Jarisch reflex was also activated before and after methyl-atropine (i.v.) in order to evaluate if the changes in mean arterial pressure were dependent on the bradycardic response. The data showed that AP-5 into the NTS produced a dose-dependent reduction in both bradycardic and hypotensive responses to activation of the Bezold-Jarisch reflex. Methyl-atropine also blocked the bradycardic and hypotensive responses to Bezold-Jarisch reflex activation. The data show that in conscious rats the cardiovagal component of the Bezold-Jarisch reflex plays a major role in the cardiovascular changes produced by the activation of this reflex and suggest that the neurotransmission of the cardiovagal component of the Bezold-Jarisch reflex is mediated by NMDA receptors.
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