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  • Title: Correlation between colposcopically directed biopsy and cervical loop excision.
    Author: Massad LS, Halperin CJ, Bitterman P.
    Journal: Gynecol Oncol; 1996 Mar; 60(3):400-3. PubMed ID: 8774646.
    Abstract:
    Colposcopy is standard for diagnosis of cervical cancer precursors, but the development of diathermy loop electrodes for excision of the cervical transformation zone offers a technique for validation. Loop excision of the transformation zone was performed for 47 consecutive women with dysplasia in colposcopically directed biopsies using 20 x 8-mm electrodes. Specimens were marked for orientation and serially sectioned. All pathology material was reviewed. Although 28% of women had disappearance of dysplasia at the biopsy site, only 9% had no dysplasia in the transformation zone. Half of the women with CIN 1 on directed biopsy had high-grade lesions found in loop excision specimens. Significant discrepancies may be found between the results of colposcopically directed biopsy and loop excision.
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