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  • Title: Canalicular cholestasis due to amiodarone toxicity. A definite diagnosis obtained by electron microscopy.
    Author: Macarri G, Feliciangeli G, Berdini V, Jezequel AM, Benedetti A.
    Journal: Ital J Gastroenterol; 1995; 27(8):436-8. PubMed ID: 8775470.
    Abstract:
    A case of jaundice due to canalicular cholestasis during amiodarone therapy is reported. A definite diagnosis was attained by ultrastructural evidence of a phospholipidosis pattern, a characteristic amiodarone-induced injury. Jaundice occurred within the third month of therapy. Serum bilirubin levels continued to increase in the two weeks following drug withdrawal. A slow decrease was observed in the following three months. Only four cases of jaundice associated with amiodarone therapy have been reported until now.
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