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  • Title: Orificial tuberculosis: detection by polymerase chain reaction.
    Author: Nachbar F, Classen V, Nachbar T, Meurer M, Schirren CG, Degitz K.
    Journal: Br J Dermatol; 1996 Jul; 135(1):106-9. PubMed ID: 8776370.
    Abstract:
    Orificial tuberculosis (OT) is a rare manifestation of cutaneous tuberculosis in immunocompromised individuals. Due to its variable clinical features, the diagnosis may be missed at the onset of the disease. We report a 53-year-old patient who had OT and miliary spread of Mycobacterium tuberculosis to the lungs, liver, bones and skin. The diagnosis was established by polymerase chain reaction (PCR) amplification of a Mycobacterium-specific gene segment, and confirmed by culture. PCR allows the detection of mycobacterial DNA within a few days, whereas culture takes many weeks. PCR may improve the accurate diagnosis of skin tuberculosis and allow early treatment.
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