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  • Title: Immunoblot analysis of immune response to cell surface antigens of different Helicobacter pylori strains.
    Author: Karczewska E, Wyle F, Tarnawski A.
    Journal: J Physiol Pharmacol; 1996 Mar; 47(1):115-20. PubMed ID: 8777291.
    Abstract:
    Infection with H. pylori has been strongly associated with chronic type B gastritis and peptic ulcer disease, although pathogenic mechanisms of H. pylori infection are still unclear. We examined the structure and antigenicity of water extract of 5 H. pylori strains and immunoblotting with homologous immune rabbit serum. All the tested rabbit sera recognized the protein component between 31-66 kD. The 31-66 kD protein bands are highly specific for H. pylori. Only strain isolated from patients with gastric or duodenal ulcer disease gave visible bands with the major proteins 98, 116 kD.
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