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  • Title: Effect of a gonadotropin-releasing hormone agonist on follicle recruitment and pregnancy rate in cattle.
    Author: Schmitt EJ, Drost M, Diaz T, Roomes C, Thatcher WW.
    Journal: J Anim Sci; 1996 Jan; 74(1):154-61. PubMed ID: 8778094.
    Abstract:
    Two experiments were conducted to determine whether a GnRH agonist eliminated a potentially persistent first-wave dominant follicle (PDF) and recruited a new dominant follicle with improved fertility upon ovulation. In Exp. 1, five nonlactating Holstein cows were treated on d 7 (d 0 = estrus) with a norgestomet implant and PGF2 alpha (25 mg); a GnRH agonist was injected on d 9. On d 16, the norgestomet implant was removed and PGF2 alpha was injected. The corpus luteum (CL) regressed (5/5 cows), and plasma progesterone (P4) decreased (P < .01) from d 7 (P4 = 10.4 +/- .3) to 9 (P4 = 1.0 +/- .3 ng/mL). The GnRH agonist induced ovulation of the first-wave dominant follicle. New dominant follicles emerged by d 12 +/- 1. In all cows, removal of norgestomet implants and injection of PGF2 alpha on d 16 caused regression (P < .01) of the CL induced by the GnRH agonist. The GnRH agonist-recruited dominant follicles were highly estrogenic on d 17 (estradiol = 19.6 +/- .8 pg/mL) and ovulated on d 19.8 +/- .2 (5/5). In Exp. 2, 147 heifers at a synchronized estrus were assigned disproportionally but randomly to two treatments (GnRHa, n = 94; PDF, n = 53). On d 7, a used controlled internal drug releasing (CIDR-B) device was inserted into the vagina and PGF2 alpha was injected. On d 9, heifers in GnRHa were injected with GnRH agonist. The CIDR-B devices were removed and PGF2 alpha was injected into all heifers on d 16. Within 4 d after removal of CIDR-B devices, 96.8 and 94.3% of heifers in GnRHa and PDF were detected in estrus and inseminated. Pregnancy rates were GnRHa = 60.6% > PDF = 43.4% (P < .05). In summary, fertility after ovulation of a persistent first-wave dominant follicle is reduced, whereas induction of a new dominant follicle following injection of a GnRH agonist results in greater fertility.
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