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  • Title: [Bronchiolitis obliterans in a patient with chronic graft-versus-host disease after bone marrow transplantation].
    Author: Matsumoto K, Yamauchi T, Ichikawa M, Masuda Y, Ogawa K, Arai T, Ito M, Yamashita Y.
    Journal: Nihon Kyobu Shikkan Gakkai Zasshi; 1996 Mar; 34(3):345-9. PubMed ID: 8778478.
    Abstract:
    A 25-year-old with acute lymphoblastic leukemia (FAB:L2) received an allogeneic bone marrow transplant from an HLA-identical sibling during the first remission. Despite administration of adequate immunosuppressant drugs, active chronic graft-versus-host disease developed and continued. The patient complained of progressive dry coughing and breathlessness on exertion 18 months after the transplant and severe hyperlucency and multiple bullae were observed on a chest X-ray film. Three years after the transplant, recurrent bilateral pneumothorax developed and lung cysts were resected twice. Histological examination revealed bronchiolitis obliterans. We speculate that post-transplant bronchiolitis obliterans caused multiple bullae to form by a check-valve mechanism, which then led to recurrent bilateral pneumothorax.
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