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  • Title: Cloning and expression of cDNA for O-acetylation of GD3 ganglioside.
    Author: Ogura K, Nara K, Watanabe Y, Kohno K, Tai T, Sanai Y.
    Journal: Biochem Biophys Res Commun; 1996 Aug 23; 225(3):932-8. PubMed ID: 8780713.
    Abstract:
    O-acetylated sialic acids of glycoproteins and gangliosides show cell type-specific and developmentally regulated expression in various systems and sometimes reappear as oncofetal antigens. O-acetylation of sialic acids may influence cell-cell interactions mediated by the sialic acid-binding lectins. Here we describe the molecular cloning and sequencing of a gene that produces O-acetyl disialoganglioside (O-acetyl GD3). Expression analysis showed that this gene product participates the O-acetylation of GD3 ganglioside sialic acid. The deduced amino acid sequence of the product was found to be similar to the milk fat globule membrane glycoprotein.
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