These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Desmutagenicity of soybean after heating.
    Author: Oshite H, Oda M, Nguyen VC.
    Journal: Biosci Biotechnol Biochem; 1996 Jul; 60(7):1152-5. PubMed ID: 8782410.
    Abstract:
    The mutagenicity and desmutagenicity of extracts of soybeans heated at 225 +/- 5 degrees C were investigated by the Ames test. The soybeans were refluxed in water, methanol, or diethylether for 2 h. The aqueous and methanol extracts (2-4 mg/plate) of the heated soybeans exhibited strong desmutagenic activity of 43-92% against heterocyclic amines (Trp-P-1. Glu-P-2, IQ, MeIQx. PhIP), while no mutagenicity was observed. The desmutagenicity of the heated soybean extracts remained even after denaturation by 0.1 N HCl in vitro and absorption by the rat small intestine. The desmutagenic mechanism for heated soybeans was evaluated, and it was verified that the soybean extract exhibited its desmutagenicity by blocking the mutagenicity of activated Trp-P-1, and not by inhibiting the S9 enzyme system.
    [Abstract] [Full Text] [Related] [New Search]