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  • Title: Experimental immunization of hamsters with an EDTA extract of Leptospira interrogans, serovar icterohaemorrhagiae.
    Author: de Queiroz-Leite LT, Resende M, Ramos-Vieira M das N, Cota-Koury M.
    Journal: Rev Latinoam Microbiol; 1996; 38(1):39-43. PubMed ID: 8783904.
    Abstract:
    The EDTA extract was prepared from the Leptospira interrogans serovar icterohaemorrhagiae. When inoculated subcutaneously in hamsters it conferred protection from challenge with virulent leptospires with a low dose (10 micrograms/ml) and low agglutinating antibody (40). The protection of animals obtained by the EDTA extract opens up the perspective of its use as a component of a vaccine for the control of leptospirosis.
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