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  • Title: [The effect of Ro 11-1781, a calciumantagonist, on atrioventricular conduction (author's transl)].
    Author: Gmeiner R, Simma H, Ng CK, Dienstl F, Knapp E.
    Journal: Z Kardiol; 1977 May; 66(5):238-41. PubMed ID: 878551.
    Abstract:
    The effect of an intravenous bolus of 1 mg/kg Ro 11-1781, a new calciumantagonist, on sinus node automaticity and intracardiac conduction was studied by His-bundle electrography and atrial stimulation. During sinus rhythm, no significant action of Ro 11-1781 on rate, P-A-interval, A-H interval, and H-V-interval was observed. The sinus node recovery time remained unaltered. On atrial stimulation, the St-H-interval was significantly (p less than 0.001) prolonged after Ro 11-1781. Wenckebach Periods occurred at lower stimulation rates in all patients after Ro 11-1781. It is concluded that Ro 11-1781 prolongs av nodal conduction and may be of therapeutic value in the treatment of supraventricular arrhythmias.
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